Last active
June 19, 2025 21:02
-
-
Save iDevPy/b334512daeace657c56e33be43370a0f to your computer and use it in GitHub Desktop.
This file contains hidden or bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
| { | |
| "id" : null, | |
| "scope" : null, | |
| "query" : null, | |
| "appliedFilters" : [ { | |
| "filter" : "region", | |
| "operator" : "equals", | |
| "value" : "Northern California", | |
| "label" : "Northern California" | |
| }, { | |
| "filter" : "dateIssued", | |
| "operator" : "equals", | |
| "value" : "[2025-04-26 TO 2025-04-28]", | |
| "label" : "[2025-04-26 TO 2025-04-28]" | |
| } ], | |
| "sort" : null, | |
| "configuration" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals" | |
| } | |
| }, | |
| "_embedded" : { | |
| "searchResult" : { | |
| "_embedded" : { | |
| "objects" : [ { | |
| "hitHighlights" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "indexableObject" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b" | |
| } | |
| }, | |
| "_embedded" : { | |
| "indexableObject" : { | |
| "id" : "372cf7c6-866e-4671-bfa5-8a8588153a1b", | |
| "uuid" : "372cf7c6-866e-4671-bfa5-8a8588153a1b", | |
| "name" : "Pathogenic germline variants among women with uterine cancer by ancestry: A commercial laboratory collaborative research registry study", | |
| "handle" : "test/36080", | |
| "metadata" : { | |
| "dc.contributor.author" : [ { | |
| "value" : "Johnson CR", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Aryasomayajula C", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Francoeur AA", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Stewart C", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Sia TY", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "Darcy KM", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "Tian C", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| }, { | |
| "value" : "Kapp DS", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 7 | |
| }, { | |
| "value" : "Liu YL", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 8 | |
| }, { | |
| "value" : "Chan JK", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 9 | |
| } ], | |
| "dc.contributor.email" : [ { | |
| "value" : "[email protected]", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.firstauthor" : [ { | |
| "value" : "Johnson CR", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.fullname" : [ { | |
| "value" : "Johnson, Caitlin R", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Aryasomayajula, Chinmayi", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Francoeur, Alex A", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Stewart, Chelsea", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Sia, Tiffany Y", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "Darcy, Kathleen M", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "Tian, Chunqiao", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| }, { | |
| "value" : "Kapp, Daniel S", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 7 | |
| }, { | |
| "value" : "Liu, Ying L", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 8 | |
| }, { | |
| "value" : "Chan, John K", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 9 | |
| } ], | |
| "dc.contributor.kaiserauthor" : [ { | |
| "value" : "Aryasomayajula, Chinmayi", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.testfirst" : [ { | |
| "value" : "False", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.location" : [ { | |
| "value" : "Santa Clara Medical Center", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.region" : [ { | |
| "value" : "Northern California", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.specialty" : [ { | |
| "value" : "Resident/Clinician-in-Training", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.accessioned" : [ { | |
| "value" : "2025-05-15T23:22:49Z", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.available" : [ { | |
| "value" : "2025-05-15T23:22:49Z", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.epub" : [ { | |
| "value" : "Epub 2025-04-28", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.issued" : [ { | |
| "value" : "2025-04-28", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.description.abstract" : [ { | |
| "value" : "Uterine cancer (UC) is the most common gynecologic cancer in the United States, and 5-15 % of patients harbor a germline pathogenic variant (gPV) in a cancer predisposition gene. This study aims to characterize the germline landscape of patients with UC by self-identified ancestry. Patients with UC who received germline testing were identified from the publicly available Myriad Collaborative Research Registry. Rates of gPVs were calculated, overall and by self-reported ancestry, with a focus on genes associated with UC, including Lynch syndrome (LS) and homologous recombination-related (HR) genes. Among 35,310 patients with UC, 23,081 (65.4 %) identified as White, 3683 (10.4 %) as Hispanic, 2132 (6.0 %) as Black, 1244 (3.5 %) as Ashkenazi Jewish (AJ), 1093 (3.1 %) as Asian, and 7550 (21.4 %) as Other. Overall, 5141 (14.6 %) patients had a gPV, with highest rates among White (15.5 %) and Asian (17.8 %) compared to Black (10.4 %) and Hispanic (11.6 %) patients, p < 0.0001. LS gPVs were observed in 3155 (8.9 %) patients and was most prevalent in Asian women (12.9 %), particularly MLH1 and MSH2-associated LS. HR-related gPVs were found in 1066 (3.0 %) patients overall and were most common in AJ (4.1 %) and Black (4.0 %) patients, with high rates of BRCA1/2 gPVs in AJ patients and non-BRCA HR-related gPVs in Black patients. Of the over 35,000 patients with UC, 14.5 % had a gPV identified, supporting consideration of universal germline testing in endometrial cancer given high actionability. We observed heterogeneity in gPVs by self-reported ancestry with Black and Hispanic patients having the lowest rates, potentially contributing to disparities in UC.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.description.dcom" : [ { | |
| "value" : "False", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.citation" : [ { | |
| "value" : "Gynecol Oncol. 2025 Apr 28;197:83-90. Epub 2025-04-28.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.doi" : [ { | |
| "value" : "10.1016/j.ygyno.2025.04.585", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.issn" : [ { | |
| "value" : "1095-6859 (Electronic)", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "0090-8258 (Linking)", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| } ], | |
| "dc.identifier.pmid" : [ { | |
| "value" : "40300426", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.uri" : [ { | |
| "value" : "https://test.com/handle/test/36080", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.language.iso" : [ { | |
| "value" : "en_US", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.relation.ispartof" : [ { | |
| "value" : "Gynecologic oncology", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.rights" : [ { | |
| "value" : "This resource is subject to copyright restrictions. The full text is for internal use only. Do not share outside of Kaiser Permanente.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.subject" : [ { | |
| "value" : "Germline pathogenic variants", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Homologous recombination variants", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Lynch syndrome", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Self-reported ancestry", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Uterine cancer", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "testPLCancerSearch", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| } ], | |
| "dc.title" : [ { | |
| "value" : "Pathogenic germline variants among women with uterine cancer by ancestry: A commercial laboratory collaborative research registry study", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.type" : [ { | |
| "value" : "Journal Article", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ] | |
| }, | |
| "inArchive" : true, | |
| "discoverable" : true, | |
| "withdrawn" : false, | |
| "lastModified" : "2025-05-20T17:15:47.214+00:00", | |
| "entityType" : null, | |
| "type" : "item", | |
| "_links" : { | |
| "accessStatus" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/accessStatus" | |
| }, | |
| "bundles" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/bundles" | |
| }, | |
| "mappedCollections" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/mappedCollections" | |
| }, | |
| "owningCollection" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/owningCollection" | |
| }, | |
| "relationships" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/relationships" | |
| }, | |
| "version" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/version" | |
| }, | |
| "templateItemOf" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/templateItemOf" | |
| }, | |
| "thumbnail" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b/thumbnail" | |
| }, | |
| "self" : { | |
| "href" : "https://test.com/server/api/core/items/372cf7c6-866e-4671-bfa5-8a8588153a1b" | |
| } | |
| } | |
| } | |
| } | |
| }, { | |
| "hitHighlights" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "indexableObject" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17" | |
| } | |
| }, | |
| "_embedded" : { | |
| "indexableObject" : { | |
| "id" : "c0dcea6c-c671-4e01-a467-8b698c149b17", | |
| "uuid" : "c0dcea6c-c671-4e01-a467-8b698c149b17", | |
| "name" : "Low levels of DNA repair enzyme NEIL2 May exacerbate inflammation and genomic damage in subjects with stable COPD and during severe exacerbations", | |
| "handle" : "test/36053", | |
| "metadata" : { | |
| "dc.contributor.author" : [ { | |
| "value" : "Cardenas VJ", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Seashore JB", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Tapryal N", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Ameri M", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Rivera R", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "Sharma K", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "Hazra T", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| } ], | |
| "dc.contributor.email" : [ { | |
| "value" : "[email protected]", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.firstauthor" : [ { | |
| "value" : "Cardenas VJ", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.fullname" : [ { | |
| "value" : "Cardenas, Victor J", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Seashore, Justin B", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Tapryal, Nisha", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Ameri, Moe", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Rivera, Rosalinda", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "Sharma, Kabir", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "Hazra, Tapas", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| } ], | |
| "dc.contributor.kaiserauthor" : [ { | |
| "value" : "Seashore, Justin B", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.testfirst" : [ { | |
| "value" : "False", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.location" : [ { | |
| "value" : "Vacaville Hospital", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.region" : [ { | |
| "value" : "Northern California", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.contributor.specialty" : [ { | |
| "value" : "Emergency Medicine", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.accessioned" : [ { | |
| "value" : "2025-05-15T23:22:39Z", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.available" : [ { | |
| "value" : "2025-05-15T23:22:39Z", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.epub" : [ { | |
| "value" : "Epub 2025-04-28", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.date.issued" : [ { | |
| "value" : "2025-04-28", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.description.abstract" : [ { | |
| "value" : "Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease that is an independent risk factor for lung cancer. Reduction in NEIL2 function, a DNA glycosylase involved in DNA repair during transcription, has been associated with an increased incidence of malignancies in humans. NEIL2 knockout mouse models have demonstrated increased inflammation and oxidative DNA damage in the lungs after exposure to an inflammatory insult, but data are lacking regarding NEIL2 function in individuals with COPD. We investigated whether NEIL2 levels and oxidative DNA damage to the transcribed genome are reduced in individuals with stable COPD and during severe acute exacerbations of COPD (AECOPD). The study was conducted at a single center in the US. Eligible subjects underwent a one-time 30 cc venous blood draw. The population consisted of 50 adults: 16 with stable COPD, 11 hospitalized for AECOPD, and 23 individuals without lung disease (controls). We analyzed blood leukocytes for NEIL2 mRNA and DNA damage by RT‒qPCR and LA‒qPCR, respectively, in all groups. Plasma levels of seven biomarkers, CXCL1, CXCL8, CXCL9, CXCL10, CCL2, CCL11 and IL-6, were analyzed in the COPD groups using a magnetic bead panel (Millipore®). The fold change in NEIL2 mRNA levels were lower in individuals with stable COPD and AECOPD than in controls (0.72 for COPD, p = 0.029; 0.407 for AECOPD, p < 0.001). The difference in NEIL2 mRNA expression between the stable COPD group and AECOPD group was also statistically significant (p < 0.001). The fold change in DNA lesions per 10 kb of DNA was greater in the stable COPD (9.38, p < 0.001) and AECOPD (15.81, p < 0.001) groups than in the control group. The difference in fold change was also greater in the AECOPD group versus stable COPD p < 0.024). Cytokine levels were not significantly different between the COPD groups. NEIL2 levels were correlated with plasma eosinophil levels in the stable COPD group (r = 0.737, p = 0.003). NEIL2 mRNA levels are significantly reduced in individuals with COPD and may exacerbate DNA damage and inflammation. These results suggest a possible mechanism that increases inflammation and oxidative genomic damage in COPD. Not applicable.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.description.dcom" : [ { | |
| "value" : "True", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.description.sponsorship" : [ { | |
| "value" : "R01 NS073976/NS/NINDS NIH HHS/United States", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "UL1 TR001439/TR/NCATS NIH HHS/United States", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "R01 NS073976, Hazra PI/NH/NIH HHS/United States", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| } ], | |
| "dc.identifier.citation" : [ { | |
| "value" : "Respir Res. 2025 Apr 28;26(1):165. Epub 2025-04-28.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.doi" : [ { | |
| "value" : "10.1186/s12931-025-03251-4", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.issn" : [ { | |
| "value" : "1465-993X (Electronic)", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "1465-9921 (Linking)", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| } ], | |
| "dc.identifier.pmc" : [ { | |
| "value" : "PMC12039275", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.pmid" : [ { | |
| "value" : "40296120", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.identifier.uri" : [ { | |
| "value" : "https://test.com/handle/test/36053", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.language.iso" : [ { | |
| "value" : "en_US", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.relation.ispartof" : [ { | |
| "value" : "Respiratory research", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.rights" : [ { | |
| "value" : "This resource is subject to copyright restrictions. The full text is for internal use only. Do not share outside of Kaiser Permanente.", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.subject" : [ { | |
| "value" : "Airway inflammation", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "COPD", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Cancer", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "DNA repair", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Eosinophils", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "Genomic damage", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "NEIL2", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| } ], | |
| "dc.subject.mesh" : [ { | |
| "value" : "Humans", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| }, { | |
| "value" : "Pulmonary Disease, Chronic Obstructive/genetics/blood/diagnosis/enzymology", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 1 | |
| }, { | |
| "value" : "Male", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 2 | |
| }, { | |
| "value" : "Female", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 3 | |
| }, { | |
| "value" : "Aged", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 4 | |
| }, { | |
| "value" : "DNA Glycosylases/blood/genetics", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 5 | |
| }, { | |
| "value" : "Middle Aged", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 6 | |
| }, { | |
| "value" : "DNA Damage/physiology", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 7 | |
| }, { | |
| "value" : "Biomarkers/blood", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 8 | |
| }, { | |
| "value" : "Disease Progression", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 9 | |
| }, { | |
| "value" : "DNA Repair/physiology", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 10 | |
| }, { | |
| "value" : "Severity of Illness Index", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 11 | |
| }, { | |
| "value" : "Inflammation/genetics/blood", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 12 | |
| }, { | |
| "value" : "Inflammation Mediators/blood", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 13 | |
| }, { | |
| "value" : "DNA-(Apurinic or Apyrimidinic Site) Lyase", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 14 | |
| } ], | |
| "dc.title" : [ { | |
| "value" : "Low levels of DNA repair enzyme NEIL2 May exacerbate inflammation and genomic damage in subjects with stable COPD and during severe exacerbations", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ], | |
| "dc.type" : [ { | |
| "value" : "Journal Article", | |
| "language" : null, | |
| "authority" : null, | |
| "confidence" : -1, | |
| "place" : 0 | |
| } ] | |
| }, | |
| "inArchive" : true, | |
| "discoverable" : true, | |
| "withdrawn" : false, | |
| "lastModified" : "2025-05-16T02:06:30.834+00:00", | |
| "entityType" : null, | |
| "type" : "item", | |
| "_links" : { | |
| "accessStatus" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/accessStatus" | |
| }, | |
| "bundles" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/bundles" | |
| }, | |
| "mappedCollections" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/mappedCollections" | |
| }, | |
| "owningCollection" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/owningCollection" | |
| }, | |
| "relationships" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/relationships" | |
| }, | |
| "version" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/version" | |
| }, | |
| "templateItemOf" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/templateItemOf" | |
| }, | |
| "thumbnail" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17/thumbnail" | |
| }, | |
| "self" : { | |
| "href" : "https://test.com/server/api/core/items/c0dcea6c-c671-4e01-a467-8b698c149b17" | |
| } | |
| } | |
| } | |
| } | |
| } ] | |
| }, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=100" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 100, | |
| "totalPages" : 1, | |
| "totalElements" : 2 | |
| } | |
| }, | |
| "facets" : [ { | |
| "name" : "Kauthor", | |
| "facetType" : "text", | |
| "facetLimit" : 10, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/Kauthor?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=10" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 10 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "Aryasomayajula, Chinmayi", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.Kauthor=Aryasomayajula,%20Chinmayi,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "Seashore, Justin B", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.Kauthor=Seashore,%20Justin%20B,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| }, { | |
| "name" : "region", | |
| "facetType" : "text", | |
| "facetLimit" : 10, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/region?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=10" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 10 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "Northern California", | |
| "count" : 2, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| }, { | |
| "name" : "center", | |
| "facetType" : "text", | |
| "facetLimit" : 10, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/center?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals" | |
| } | |
| }, | |
| "_embedded" : { | |
| "values" : [ ] | |
| } | |
| }, { | |
| "name" : "contributorlocation", | |
| "facetType" : "text", | |
| "facetLimit" : 10, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/contributorlocation?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=10" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 10 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "Santa Clara Medical Center", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.contributorlocation=Santa%20Clara%20Medical%20Center,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "Vacaville Hospital", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.contributorlocation=Vacaville%20Hospital,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| }, { | |
| "name" : "dateIssued", | |
| "facetType" : "date", | |
| "facetLimit" : 5, | |
| "minValue" : "1/1/2014", | |
| "maxValue" : "Spring-2016", | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/dateIssued?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=5" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 5 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "2025", | |
| "count" : 2, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.dateIssued=2025,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| }, { | |
| "name" : "contributorspecialty", | |
| "facetType" : "text", | |
| "facetLimit" : 10, | |
| "_links" : { | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/contributorspecialty?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=10" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 10 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "Emergency Medicine", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.contributorspecialty=Emergency%20Medicine,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "Resident/Clinician-in-Training", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.contributorspecialty=Resident/Clinician-in-Training,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| }, { | |
| "name" : "subject", | |
| "facetType" : "hierarchical", | |
| "facetLimit" : 5, | |
| "_links" : { | |
| "next" : { | |
| "href" : "https://test.com/server/api/discover/facets/subject?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&page=1&size=5" | |
| }, | |
| "self" : { | |
| "href" : "https://test.com/server/api/discover/facets/subject?f.region=Northern California,equals&f.dateIssued=[2025-04-26 TO 2025-04-28],equals&size=5" | |
| } | |
| }, | |
| "page" : { | |
| "number" : 0, | |
| "size" : 5 | |
| }, | |
| "_embedded" : { | |
| "values" : [ { | |
| "label" : "Airway inflammation", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.subject=Airway%20inflammation,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "Cancer", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.subject=Cancer,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "COPD", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.subject=COPD,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "DNA repair", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.subject=DNA%20repair,equals" | |
| } | |
| } | |
| }, { | |
| "label" : "Eosinophils", | |
| "count" : 1, | |
| "authorityKey" : null, | |
| "type" : "discover", | |
| "_links" : { | |
| "search" : { | |
| "href" : "https://test.com/server/api/discover/search/objects?f.region=Northern%20California,equals&f.dateIssued=%5B2025-04-26%20TO%202025-04-28%5D,equals&f.subject=Eosinophils,equals" | |
| } | |
| } | |
| } ] | |
| } | |
| } ] | |
| } | |
| } |
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment