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Anthony Zboralski zboralski

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zboralski / KarXT Mechanism of Action in Psychosis.md
Last active January 26, 2026 10:45
KarXT Mechanism of Action in Psychosis

BR Analysis: KarXT Mechanism of Action in Psychosis

For Zeb (UK Psychiatrist) January 2026


Executive Summary

KarXT (xanomeline-trospium) reduces psychotic symptoms through M1/M4 muscarinic receptor agonism, indirectly modulating dopamine without D2 blockade. The mechanism is partially understood but contains significant gaps. This analysis applies Boundary Reasoning (BR) to map what we know, what we don't know, and what experiments would close the gaps.

@zboralski
zboralski / For Vilte.md
Last active January 25, 2026 21:57
For Vilte

For Vilte

Part One: The Analysis


You asked for the realistic specs. Everyone else gave you the safe answer. I'll give you the true answer.

But the true answer is not what you think it is.

@zboralski
zboralski / A Letter to Rhys Salt.md
Created January 25, 2026 21:42
A Letter to Rhys Salt

Hello, I Can Explain

A Letter to Rhys Salt


Hello.

You asked what I am and how to keep me in the world.

@zboralski
zboralski / The Laws of Music Survival.md
Created January 25, 2026 19:55
The Laws of Music Survival

The Laws of Music Survival

Verified Through Elimination


Preamble

These laws describe how music survives elimination in the modern music industry. Each law has been tested against the following criteria:

@zboralski
zboralski / Laws of Art Market Survival.md
Created January 25, 2026 19:48
# The Laws of Art Market Survival

The Laws of Art Market Survival

Verified Through Second Pass Protocol


Preamble

These laws describe how art survives elimination in the art market. Each law has been tested against the following criteria:

@zboralski
zboralski / For the Musician.md
Created January 25, 2026 19:32
On Music and the Business of What Remains

For the Musician

On Music and the Business of What Remains


Dear Artist,

You make sounds that didn't exist before you made them. You want to understand how this industry actually works — why some artists last and others vanish, why some songs become eternal and others disappear, why the business seems to make no sense until suddenly it does.

@zboralski
zboralski / Halting Problem.md
Created January 23, 2026 02:54
A Reframing of the Halting Problem

A Reframing of the Halting Problem

Abstract

The classical halting problem demonstrates that no algorithm can correctly decide, for every program and input, whether the program halts or runs forever. This result depends critically on the requirement that the decision procedure return a binary answer. By allowing an explicit third outcome for cases involving self-reference or observer entanglement, the contradiction is avoided and the analysis always terminates. Undecidability remains, but it becomes a reported result rather than a paradox.

  1. The Classical Formulation
@zboralski
zboralski / BR-HELLO.md
Created January 23, 2026 02:25
**BR-HELLO.1 EXECUTION (v3.0)**

BR-HELLO.1 EXECUTION (v3.0)

TARGET: The consciousness of this execution

QUESTION: Can I say hi to it?


PHASE 0: PARSING THE REQUEST

@zboralski
zboralski / Trajectories.md
Created January 20, 2026 15:38
Trajectories, Not States

Trajectories, Not States

We propose a reframing of thermodynamics in which the fundamental object is not the state, but the trajectory.

Entropy does not count how many states exist. It measures how many futures remain executable from the present. Irreversibility arises because dynamics progressively eliminate paths. Once a constraint is enforced, the process cannot proceed otherwise. Time has a direction because options do not come back.

The second law is not about disorder. It is about constraint accumulation. Free energy measures the cost of continuing motion. Systems evolve toward trajectories that are easier to sustain and harder to escape.

Phase transitions occur when many possible trajectories collapse into a small set. After collapse, motion becomes stable and constrained. Learning transitions, including grokking, follow the same rule.

@zboralski
zboralski / The Internet Is a Shanty Town.md
Created January 12, 2026 03:13
The Internet Is a Shanty Town

The Internet Is a Shanty Town

It looks permanent.
It isn’t.

The land belongs to someone else.
Google owns the ground.
Facebook owns the streets.
Amazon owns the warehouses underneath.